Home Medicine PA Boards 72: Is it safe to combine a macrolide and a... MedicinePodcast PA Boards 72: Is it safe to combine a macrolide and a statin? By Andrew - September 22, 2015 SHARE Facebook Twitter Listen on iTunes here Listen on Stitcher here So, does it even matter? Should you avoid this combination because of the risk of rhabdomyolysis? I would argue no – and the risk isn’t even clinically significant. Take a listen to hear why.